Today’s Visualized peers into a teeny tiny microscope. But first, catch up on the latest science news, including a cool way of generating electricity and concerns about how the U.S. government is handling fetal tissue research.
Genetics | Science
Plants have a surprisingly low genetic threshold for speciation
Plants have a bit of a reputation for playing fast and loose with genetic rules, allowing them to hybridize more readily than animals. Indeed, it’s long been dogma that the genomic bar for speciation is much higher in flora than in fauna—but that’s not the case. Quite the opposite, it turns out.
Researchers looked at 280 closely related pairs of plant species and 61 pairs of animals, determining how different their genomes are as well as searching for evidence of recent gene flow. They found that the likelihood of interbreeding drops off as soon as plants differ by about 0.3% across their genomes, while for the animals the decline didn’t start until about 1.8% divergence.
Why, then, did scientists think plants are so much more flexible about the similarity of their mating partner? In a related Perspective, Yaniv Brandvain points out that the study looked at genetic signatures of hybridization, not whether the species can successfully be crossed. So one possibility is that what works in a greenhouse just doesn’t happen in natural environments. “For example, plants cannot walk or fly and therefore may be more geographically isolated (less opportunity for gene flow) than are animals,” he writes.
Every solid exhibits some amount of electric response to being bent or deformed, called flexoelectricity. Most of these responses are far too weak to exploit—the world isn’t just a battery waiting to be tapped. But when researchers turned to ice, a prevalent solid on Earth and one of the most common solids in space, the story was different. Adding table salt (NaCl) created a solid where every ice particle was surrounded by a few nanometers of briny liquid. When the salty ice was bent and unbent, this fluid sloshed back and forth, creating a current of ions that conferred a flexoelectrical effect around 1000 times larger than that of pure ice and on par with specially designed materials.
Salty ice has plenty of advantages in the real world, such as being moldable (just think of fun-shaped ice trays), non-toxic, and requiring no trace elements, as found in typical electronics. The simple solid could be incorporated into engineering projects in polar areas where sunlight is too low for solar power and water threatens soft robotics’ wiring and batteries, though it’s not a great candidate for deep space applications since the key briny liquid freezes at -70ºC. In a related News & Views, materials scientist Daesu Lee writes that the work is important for “ reminding us that dramatic effects can sometimes be found in plain sight.”
Scientists decry NIH pledge to defund some fetal tissue research
The National Institutes of Health (NIH) says it will not renew a handful of research grants that an advocacy group identified as involving human fetal tissue—a decision that is setting off alarm bells for some in the scientific community.
The White Coat Waste Project, a self-described “taxpayer watchdog” that campaigns to eliminate animal research across the federal government, last week publicized a list of 17 grants categorized in NIH’s grants database as active and listed under the spending category “human fetal tissue.” The list encompasses a variety of projects, including studies focused on human brain development, childhood cancer, and treatments for HIV. Many involve using fetal tissue donated from elective abortions to develop humanized mice that model the human immune system, which can be used to study diseases and test drugs. But it’s not clear whether all of the studies actually involved the controversial material—or whether NIH’s pledge not to renew them signals the revival of restrictive policies on fetal tissue studies that President Donald Trump imposed during his first term in office to satisfy abortion opponents.
Still, the International Society for Stem Cell Research protested the move, citing the scientific and clinical importance of studies involving human fetal tissue. “We urge NIH to reject political pressure to discontinue research with [human fetal tissue] and instead reaffirm its role as a champion of evidence-based biomedical science,” society president Hideyuki Okano said in a statement.
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DeepInMiniscope combines optical technology and machine learning to create a device that can take high-resolution 3D images inside living tissue. Mario Rodriguez/UC Davis
iPhones are getting thinner, drones are getting lighter, and scientists have designed a microscope the size of a grape. The scope, weighing only 10 grams and measuring three centimeters in length, was made to track a mouse’s brain activity in real time.
The device, called DeepInMiniscope, aimed to be a less-invasive tool for imaging the brain. But first, it needed to solve basic issues with imaging biological systems, including light scattering, low contrast levels, and intricate subject matter. Rather than using a single camera lens with one big input, the researchers opted for more than 100 mini, high-resolution lenslets in their design. The data from each lens then fed into a neural network that reconstructed the complete picture in 3D.
A tiny hydra in living color. Tian et al./Science Advances (2025)
To test the device, the team imaged a roundworm and live hydra (pictured above), both dyed with fluorescent proteins. DeepInMiniscope captured roundworm embryos and hydra tentacles down to 13 and 20 micrometers, respectively. Then, the researchers moved on to their intended target: the brain of an awake mouse. They successfully captured its spontaneous neural activity without the mouse being anaesthetized.
Going forward, the researchers hope to make an even smaller device at two centimeters, a size they compare to a hat for a mouse. They also aim to speed up the image capturing speed, as well as iterate on the neural networks so the whole process goes more smoothly. Given its noninvasiveness, the authors hope the microscope can one day be used in real time on live patients to better assess the roots of their behavior.
Earlier this year, a ScienceInsider analysis found that seven of the eight new members of the CDC Advisory Committee on Immunization Practices (ACIP) panel had, on average, only 11 papers related to vaccines, compared to the 49 papers averaged by the previous members who had been dismissed RFK Jr. He added five new members before this week’s ACIP meeting; four have no papers at all while the fifth has 11 but few truly on vaccination.
The dinosaurs had such an impressive impact on their environment that they should be considered ‘ecosystem engineers,’ according to the authors of a recent paper examining geological changes that occurred after the impact that wiped out the nonavian ones. “These things were monsters compared to what you have today,” one noted.
Nephrologist Drummond Rennie, who helped found the field of journalology (the study of best publishing practices) and organized the first Peer Review Congress, died last week. In a 2018 feature story, Rennie said the effort to convince people to study journals was “exhausting and exhilarating.”
With contributions from Hannah Richter and Phie Jacobs
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